1 State Key Laboratory of Functions and Applications of Medicinal Plants, Guizhou Medical University, Guiyang 550025, China; 2 The High Efficacy Application of Natural Medicinal Resources Engineering Center of Guizhou Province(The Key Laboratory of Optimal Utilization of Natural Medicine Resources), School of Pharmaceutical Sciences, Guizhou Medical University, Guiyang 550025, China; 3 Engineering and Research Center for Southwest Bio-Pharmaceutical Resources of National Education Ministry of China, Guizhou University, Guiyang 550025, China; 4 Department of Botany, Khushal Khan Khattak University, Karak, KP, Pakistan; 5 Immune Cells and Antibody Engineering Research Center of Guizhou Province/Key Laboratory of Biology and Medical Engineering, Guizhou Medical University, Guiyang 550025, China; 6 Key Laboratory of Infectious Immune and Antibody Engineering of Guizhou Province, Engineering Research Center of Cellular Immunotherapy of Guizhou Province, School of Biology and Engineering/School of Basic Medical Sciences, Guizhou Medical University, Guiyang 550025, China †These authors contributed equally as first authors to this work. *Authors for correspondence. Xiang-Chun Shen. E-mail:shenxiangchun@126.com;Ji-Chuan Kang. E-mail:jckang@gzu.edu.cn