Menispermaceae are a pantropical and temperate family with an extensive fossil record during the Paleogene, especially in North America and Europe, but with much less evidence from Asia. The latest fossil evidence indicates a succession of tropical to sub-tropical flora on the central Tibetan Plateau during the Paleogene. However, the biogeographic histories of these floras are still unresolved. Here, we report on endocarps and leaves of Menispermaceae from the Middle Eocene of Jianglang village, Bangor County, central Tibetan Plateau. The endocarps belong to two genera: Stephania which is characterized by a horseshoe-shaped endocarp and with one lateral crest ornamented by spiny to rectangular ribs, and a condyle area; Cissampelos has two characteristic lateral ridges and a conspicuous external condyle. Associated leaves belong to the genus Menispermites, and are characterized by actinodromous primary venation, brochidodromous secondary veins, entire margins, and the presence of marginal secondary veins. The biogeographic history of Menispermaceae is complex, but evidence from these new fossils indicates an early diversification of the group in Asia, probably in response to the warming climate during the Eocene. The Jianglang flora appears to be part of a boreotropical flora, connecting Asia with North American and European floras during the Middle Eocene. The modern distribution of Menispermaceous taxa found in Jianglang, as well as other families represented in the Jianglang flora, show that a tropical to sub-tropical climate occurred during the Eocene in central Tibet.