1 Shandong Key Laboratory of Eco-Environmental Science for the Yellow River Delta, Binzhou University, Binzhou 256600, China; 2 School of Environment, Beijing Normal University, Beijing 100875, China; 3 Wuhan Frasergen Bioinformatics Co. Ltd., Wuhan 430070, China †These authors contributed equally to this work and should be considered co-first authors. *Authors for correspondence. Jiang-Bao Xia. E-mail: xiajb@163.com; Jun-Hong Bai. E-mail: junhongbai@163.com