Telomere-to-telomere genome and multi-omics analysis provides insights into the genomic evolution and nutritional composition of Canavalia gladiata

doi:10.1111/jse.70108

Telomere-to-telomere genome and multi-omics analysis provides insights into the genomic evolution and nutritional composition of Canavalia gladiata

Yi Wang^{1, 2}, Meng Yan^{1, 2}, Pingli Xie^{1, 2}, Jinyin Xing^{2, 3}, Dongming Fang⁴, Xianzhi Wang¹, Shilai Zhang¹, Yujiao Zhang¹, Tong Wei^{1, 2, 4*}, and Xing Guo^{1, 2, 4*}

1 School of Agriculture, Yunnan University, Kunming 650500, China;
2 BGI Research, Wuhan 430047, China;
3 College of Life Sciences, Northeast Forestry University, Harbin 150040, China;
4 State Key Laboratory of Genome and Multi-omics Technologies, BGI Research, Shenzhen 518083, China
^*Authors for correspondence. Tong Wei. E-mail: weitong@genomics.cn; Xing Guo. E-mail: guoxing@genomics.cn

Received:2026-01-17 Accepted:2026-06-01 Online:2026-09-13
Supported by:
This research was supported by a grant from the National Natural Science Foundation of China (Grant No. 32000171) awarded to X. Guo. This work was also supported by the State Key Laboratory of Genome and Multi-omics Technologies. We are grateful to Fang Wang and Yaqian Wang for general discussion.

Abstract

Abstract: Canavalia gladiata (Jacq.) DC. is a leguminous crop notable for its high protein content and oil rich in unsaturated fatty acids, positioning it as a valuable genetic resource for the diversification and nutritional improvement of legume species. Here, we report a gap-free telomere-to-telomere (T2T) genome assembly of C. gladiata and perform phylogenomic analyses to reconstruct its evolutionary history. Integrative transcriptomic and metabolomic profiling further revealed the transcriptional regulatory networks underlying the biosynthesis of key nutritional metabolites, including amino acids and lipids. These findings lay a foundation for accelerating molecular breeding for improved nutritional quality in C. gladiata. The T2T assembly and multi-omics resources presented herein serve as valuable references for comparative genomics and the genetic improvement of legume crops.

Key words: Canavalia gladiata, metabolomics, seed development, T2T genome, transcriptomics

Yi Wang, Meng Yan, Pingli Xie, Jinyin Xing, Dongming Fang, Xianzhi Wang, Shilai Zhang, Yujiao Zhang, Tong Wei, Xing Guo. Telomere-to-telomere genome and multi-omics analysis provides insights into the genomic evolution and nutritional composition of Canavalia gladiata[J]. J Syst Evol, DOI: 10.1111/jse.70108.

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URL: https://www.jse.ac.cn/EN/10.1111/jse.70108

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Telomere-to-telomere genome and multi-omics analysis provides insights into the genomic evolution and nutritional composition of Canavalia gladiata

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